1 return in blocks procs and lambdas
Báo cáo y học: " Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks" potx
Ngày tải lên :
13/08/2014, 09:20
... were obtained after stimulation for three days with phytohemagglutinin (PHA, µg/ml) and interleukin-2 (IL2) (Chiron, France, 100 IU/ml) and were maintained in RPMI 1640 medium containing 10% fetal ... neutralizing anti-β-chemokines in each case, and are the mean of three independent infections ± standard deviation ** Significant difference (P < 0.001 and P = 0.008 for W278 and B195, respectively, independent ... recombinant β-chemokines RANTES, MIP-1α and MIP-1β (R&D systems, France) for 30 minutes prior to and during infection The mixtures contained the three chemokines at concentrations ranging from 500 ng...
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Investment evaluation methods and required rate of return in finish publicly listed companies
Ngày tải lên :
17/12/2013, 15:08
... commonly in the companies In Finland, Honko and Virtanen (1975), Virtanen (1984), and most recently Keloharju and Puttonen (1995) have surveyed the investment evaluation criteria and planning horizon ... in publicly listed companies in Finland Our study also extends the Keloharju and Puttonen (1995) study by focusing in more detail into how the required rate of return is set by the company Finally, ... Graham and Harvey (2001) Sweden seems to fall in between Finland according to the older surveys, and the U.S., since Sandahl and Sjögren (2003) find that 78.1 percent of the largest Swedish com14...
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Tài liệu Báo cáo khoa học: Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves ppt
Ngày tải lên :
18/02/2014, 18:20
... SCs have been implicated in human in ammatory demyelinating neuropathies such as ´ Guillain–Barre syndrome and chronic in ammatory demyelinating polyneuropathy [31] In experimental autoimmune ... of SAPK ⁄ JNK in mediating LPS-induced ICAM-1 expression in SCs JNK phosphorylates c-Jun and ATF-2 and increases their ability to activate transcription, leading to c-jun induction and subsequent ... of MAPKs in LPS-induced ICAM-1 synthesis Using U0126 (an MEK1 ⁄ inhibitor), SB202190 (a p38 MAPK inhibitor) and SP600125 (an SAPK ⁄ JNK specific inhibitor), the roles of MAPKs in LPSinduced ICAM-1...
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Real Return Bonds, Inflation Expectations, and the Break-Even Inflation Rate ppt
Ngày tải lên :
06/03/2014, 08:20
... between the interest rate measure and realized inflation Kandel, Ofer, and Sarig justify this proxy with the following example: in a given month, investors not transact in all goods included in the ... by Crawford and Date Kasumovich (1996).19 Both measures of inflation uncertainty fail to indicate a rise in inflation uncertainty in 1994, or an important decline in 1997 Crawford and Kasumovich’s ... should be influenced by inflation expectations over many different horizons, and we are also interested in determining whether the BEIR contains useful information about inflation (CPI excluding taxes...
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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
Ngày tải lên :
15/03/2014, 11:20
... in regulating the rate of protein synthesis and cell hypertrophy in skeletal muscle [3–6] mTOR is a serine ⁄ threonine kinase of the phosphatidylinositol kinase-related kinase family and is highly ... phosphoinositide 3-kinase (PI3K) and its downstream effector Akt, triggering multiple downstream signaling events, including mTOR activation [8] Studies in both Drosophila and mammalian cells have indicated ... Phosphorylation of Akt and S6K1 was induced within 10 min, and was maintained for at least 60 Altered distributions of TSC1 and TSC2 proteins were also detected on the same time scale as the Akt and S6K1 phosphorylations...
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Báo cáo khoa học: a-1 Antitrypsin binds preprohepcidin intracellularly and prohepcidin in the serum pdf
Ngày tải lên :
16/03/2014, 01:20
... preprohepcidin binding Table In vivo interactions of a-1 antitrypsin with preprohepcidin, prohepcidin and mature hepcidin Insert in pBT Insert in pTRG Growth on CTCK platesa Preprohepcidin Prohepcidin ... After binding hepcidin, ferroportin is internalized, phosphorylated, ubiquitinated and degraded by hepatocytes and macrophages [18,19] The action of hepcidin is different in intestinal cells: instead ... cultures were incubated at 30 °C overnight with shaking at 140 r.p.m Recombinant pBT and cDNA containing pTRG were isolated using a QIAprep Spin Miniprep Kit (Qiagen Inc.) and transformed into BacterioMatch...
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Báo cáo khoa học: Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans pot
Ngày tải lên :
16/03/2014, 03:20
... observed as strong punctate staining in intestinal cells and in the epidermis The number and intensity of fluorescent structures increased strongly in the intestine during larval development (Fig ... RCE1182) In brief, control and RNAi strain cultures were grown for h in LB medium containing 100 mgÆmL)1 ampicillin, and then spread onto NGM agar containing isopropyl thio-b-dgalactoside (1 mm) and ... staining is present in the pharynx (arrows) and the body wall muscles (arrowheads), and a weaker signal is observed in the intestine (G) In the pharynx, a very regular expression of GSTK2::GFP in...
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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
Ngày tải lên :
16/03/2014, 18:20
... domain ERM contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory domain is poorly conserved and virtually specific to ERM, and the C-terminal ... target sites in different genes In addition promoter sequences flanking the Ets motif determine activity through protein–protein interactions between Ets factors and factors binding at adjacent ... tenfold in SK-N-SH and cells Further deletion to +42 increased transcription in both cells lines: about fivefold in SH-SY5Y cells and twofold in SK-N-SH cells Further deletions to +6 did not result in...
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Báo cáo khoa học: Glycogen synthase kinase 3b and b-catenin pathway is involved in toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages ppt
Ngày tải lên :
22/03/2014, 21:21
... GSK3b-b-catenin is involved in Nox1 expression A β-catenin β-actin 15 30 45 60 LPS (min) B β-catenin β-actin 10 50 100 500 LPS (ng·mL–1) C β-catenin (short) β-catenin (long) β-tubulin 15 30 45 60 ... for the indicated times and fractionated into cytosolic and nuclear extracts Western blot on both extracts was determined by using anti(b-catenin) serum b-Tubulin served as loading control and nuclear ... atherosclerosis Materials and methods Reagents Cell culture reagents, including fetal bovine serum, were obtained from Life Technologies (Grand Island, NY, USA) GSK3b, b-catenin and b-actin antibodies were...
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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
Ngày tải lên :
23/03/2014, 06:20
... target proteins in vivo The attachment of SUMO may result in diverse effects on the substrate protein, including cellular and subnuclear localization [20,21], changes in stability [22] and transcriptional ... by phosphorylation following 4b-phorbol 12-myristate 13-acetate (PMA) induction [18], and serine residues 238 and 243 in the hinge region of human LRH-1 are important in this PMA-dependent transactivation ... synthesized in vitro and incubated with recombinant SUMO-1 protein, E1 (SAE1 ⁄ SAE2) and E2 (UBC9) enzymes Upon separation of the reaction products by SDS ⁄ PAGE, a slowermigrating band at approximately...
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Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt
Ngày tải lên :
23/03/2014, 17:21
... dissociation of thrombin from TM, explaining the observed biphasic inhibition profiles These findings are in marked contrast to the binding of all other thrombin-binding components, and comprise yet ... type plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin Biochim Biophys Acta 1078, ... Latent PAI-1 was obtained by incubating 200 nM PAI-1 at 37 °C for at least 20 h Direct binding of rl-TM and solulin to VN was studied by injecting 40 lL 200 nM rl-TM, or lM solulin, in the absence...
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Báo cáo khoa học: Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm pdf
Ngày tải lên :
30/03/2014, 15:20
... SIK1 and Ser587 in SIK2, are indicated in bold The basic residues in domain 3B are indicated by underlines The similarity between SIK1 and SIK2 in domain 3A, the N-terminal half of domain 3, ... Calmodulin kinase II attenuation of gene transcription by preventing cAMP response 17 18 19 20 21 22 23 24 25 26 27 28 29 element-binding protein (CREB) dimerization and binding of the CREB-binding ... nuclear and cytoplasmic salt-inducible kinase (SIK1) mutants repress cAMP-response element (CRE)/CRE-binding protein (CREB) activities (A) The protein kinase A (PKA)-induced CRE activity, and its...
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báo cáo hóa học:" Caveolin-1 enhances resveratrol-mediated cytotoxicity and transport in a hepatocellular carcinoma model" docx
Ngày tải lên :
18/06/2014, 15:20
... reduction in cell death in CAVM1 cells An intriguing mechanism, in this regard, is the presence of scaffolding domain in caveolin1 that binds to and inhibits the activity of several signaling proteins ... increase in cell number in sub-G1 and G0/G1 phase, with a corresponding decrease in other phases Interestingly, concentrations of RES between 10 and 100 μM induced a modest but reproducible increase ... signaling proteins in vitro and in situ, including the EGF and Neu receptors, Src-family kinases (Src/Fyn), PKCs, eNOS and the heterotrimeric G-proteins [32] Thus, it remains to be explained why over-expression...
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Fate of Pharmaceuticals in the Environment and in Water Treatment Systems - Chapter 1 pot
Ngày tải lên :
18/06/2014, 16:20
... regulatory and technical community and has prompted interest in sponsoring research that defines the composition and concentrations of PPCPs in potential sources and their fate and effects following ... Pharmaceuticals in the Environment and in Water Treatment Systems TABLE 1.2 Concentrations of Pharmaceuticals and Other Emerging Contaminants in Sludges and Biosolids, Sediments, Groundwater, and Drinking ... still have been detected in finished drinking water (Table 1.2) The infrequent detection of PPCPs in finished drinking water may reflect the relative efficiency of drinking-water treatment technologies...
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Behaviour of Electromagnetic Waves in Different Media and Structures Part 1 pdf
Ngày tải lên :
19/06/2014, 19:20
... electromagnetic waves in layered lossy and dispersive medium and after the physical forward modeling experiment, in chapter 7, the delamination in polished wall paintings by wall coupling antennas using GPR ... line, a and b are the inner and outer radii of the coaxial line, respectively, γ0 is the absolute value of the propagation constant in free space (see (16)), Si and J0 are the sine integral and ... consists in not making any assumption on the dispersive laws and in determining the real and imaginary parts of the material complex parameters at each measurement frequency (on a point-by-point basis)...
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Recent Advances in Wireless Communications and Networks Part 1 pptx
Ngày tải lên :
19/06/2014, 19:20
... Kao-Peng Chou and Jia-Chin Lin Chapter Synchronization for OFDM-Based Systems 23 Yu-Ting Sun and Jia-Chin Lin Chapter ICI Reduction Methods in OFDM Systems 41 Nadieh M Moghaddam and Mohammad Mohebbi ... research in theory and engineering development in practice, and as a messenger between the technical pioneers and the researchers who followed in their footstep This book, titled Recent Advances in ... practicing and knowledgeable communication X Preface engineers to beginning or professional researchers All interested readers can easily find noteworthy materials in much greater detail than in...
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Risk Management in Environment Production and Economy Part 1 doc
Ngày tải lên :
19/06/2014, 19:20
... in the Mining Industry Undram Chinbat Chapter A Fuzzy Comprehensive Approach for Risk Identification and Prioritization Simultaneously in EPC Projects 123 R Tavakkoli-Moghaddam, S.M Mousavi and ... management in economic sector to face the dynamicity and unforeseen events which can arise and, thus, better understand and tackle the actual global economy Prof Matteo Mario Savino, Dept of Engineering, ... definition of a new defence line, on the coast line but into the estuaries and bank rivers too So it is in question of a voluntary approach and pro-active, in opposition to “inactive realignment” limited...
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New Perspectives in Biosensors Technology and Applications Part 1 docx
Ngày tải lên :
19/06/2014, 21:20
... efficiency and highly demanding operations So these kinds of methods are hard to promote With the increasing demand in application, portable and low power consuming microchemical analysis detection instruments ... Sionex Company was founded in the USA in 2000, and is mainly engaged in the research and development of mico-FAIMS detection parts, and it is leading in the utility and commercialisation of the ... spectrograph, and can bring ion filtration and selection to the mass spectrograph, resulting in decreased background noise and improved signal to New Perspectives in Biosensors Technology and Applications...
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